If You Take Prilosec, Nexium, or Zantac, You NEED To Watch This
Feb 16, 2026
Description
Millions of Americans rely on common heartburn medications like Prilosec, Nexium, and Zantac for daily relief, with up to 70% of users possibly getting no benefit from them. But what if the long-term cost of that "relief" is far greater than you imagine? This is a critical warning you need to hear.
In this episode, Dr. Mark Hyman exposes the significant long-term side effects of these popular drugs, known as PPIs and H2 blockers. He explains how they can lead to serious nutritional deficiencies by blocking the absorption of B12, magnesium, and calcium. These deficiencies are linked to a host of devastating health issues, including an increased risk of dementia, neurologic problems, osteoporosis, and hip fractures. Observational studies have even linked their use to a higher risk of C. diff infections, pneumonia, heart attacks, and heart failure.
Dr. Hyman also reveals the great irony of acid reflux: for many, it's caused by too little stomach acid, not too much. He breaks down the true root causes—from diet and stress to gut imbalances—and provides a functional medicine toolkit with natural solutions to heal your gut so you can get off these medications for good.
(0:00) Introduction to the episode: Vitamin B12 deficiency and acid reflux
(1:52) Risks and side effects of proton pump inhibitors
(7:35) Challenges in discontinuing PPIs and rebound hypersecretion
(8:08) Functional medicine approach to heartburn and reflux
(10:19) Delayed gastric emptying: Causes and effects
(13:06) Low stomach acid, Helicobacter pylori, and their role in reflux
(14:39) Functional medicine solutions and dietary changes for reflux
(19:38) Closing remarks on addressing root causes
































